Thatcher Directed Study Skin 609

Question Answer
Microfilaments Actin & Myosin
Actin structural microfilaments composed of F actin
F Actin G actins polymerized into a double helix
G actin monomeric actin subunits
Spectrin actin crosslinking protein that forms networks in erthyrocytes
Dystrophin actin crosslinking protein that forms networks in striated muscle
Myosin a structural microfilament as well as a motor protein for actin
actomyosin actin and myosin associated with each other
stress fibers bundles of actomyosin anchored to the basal surface of fibroblasts which are themselves attached to substratum. produce tension across a cell layer
Microtubules polymers of alpha and beta tubulin, Tau and MAPs
Tau and MAPs microtubular crosslinking proteins that form networks
Intermediate filaments structural component of cytoskeleton. complexes composed of proteins that have similar alpha helical cores. distinctive terminal domains
keratin major intermediate filament of epithelial cells ex. hair and nails
nuclear lamins intermediate filaments supporting the nuclear membrane
Extracellular Matrix collagens, elastin, fibrillin, glycosaminoglycans, hyaluronans, proteoglycans, heparin, laminin, fibronectin
collagens extracellular matrix fibers that resist stretching, composed of 3 helices coiled around each other in a triple helix
elastin stretchable extracellular matrix fibers that provide tissues with pliability
fibrillin glycoprotein microfibrils that provide a scaffold for assembly of elastic fibers
glycosaminoglycans polysaccharides of the extracellular matrix composed of disaccharide repeats of modified sugars
hyaluronans a particularly large glycosaminoglycan that exists free in the extracellular matrix
proteoglycans extracellular matrix components, composed of core proteins attached to one or more glycosaminoglycans
heparin a regulatory proteoglycan control inflammation
laminin extracellular matrix crosslinking protein with multiple binding domains for different factors
Junctions zona occludens, gap junctions, zonula adherens, circumferential belt, spot desmosomes, hemidesmosomes, focal adhesions, membrane-microfilament binding proteins
Zonula occludens thin bands of membrane around the apical perimeters of epithelial cells, held closely together by proteins such as occludin and claudin. they seal cells to prevent diffusion of molecules across the epithelium
gap junctions transmembrane complexes that allow diffusion of small molecules between cells to vesicles
zonula adherens rows of structures anchoring actin microfilaments to the apical surface of epithelial cells, just beneath the tight junction
circumferential belt microfilament bundles (actin and myosin) that encircle the apical perimeter of epithelial cells at the level of the belt desmosomes
hemidesmosomes structures that anchor the intermediate filament cytoskeleton of an epithelial cell the basal lamina
focal adhesions structures that anchor microfilament stress fibers to the basal surface of many cells, particularly epithelial cells
membrane-microfilament binding proteins membrane associated proteins that anchor the microfilament cytoskeleton to the plasma membrane by binding actin crosslinking proteins
Crosslinking proteins factors that bind filaments together
networks filaments crosslinked into three dimensional, crisscrossed meshworks, can resist both stretching and compression
bundles filaments crosslinked in parallel to form fibers that resist stretching

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